Key features and details
- Na+ channel blocker
- CAS Number: 4368-28-9
- Purity: > 98%
- Soluble in pH 4.8 citrate buffer to 100 mM
- Form / State: Solid
- Source: Fugu
Product nameTetrodotoxin, Na+ channel blocker
DescriptionNa+ channel blocker
Potent, selective and reversible, use-dependent inhibitor of voltage-dependent Na+ channels.
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Chemical nameOctahydro-12-(hydroxymethyl)-2-imino-5,9:7,10a-dimethano-10aH-[1,3]dioxocino[6,5-d] pyrimidine-4,7,10,11,12-pentol
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in pH 4.8 citrate buffer to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
TTX blocked the ictal discharge in both field A and B neurons, but not the direct response of field A neurons to a double NMDA pulse (black arrowheads).
Multiple connections between CA3 and CA1 pyramidal cells and GABAergic cells and CA1 pyramidal cells in young adult rats. (A1) A typical recording at -80 mV from a pyramidal cell, upper trace shows AMPA sEPSCs under control conditions and lower trace shows mEPSCs after wash-in of TTX. (A2) TTX reduces the AMPA EPSC amplitude by 5.9 ± 0.8 pA (P = 0.004, n = 8, two-tailed paired t-test). (A3) TTX reduces AMPA EPSC frequency by 1.5 ± 0.4 Hz (P < 0.001, n = 8, one-tailed paired t-test). (A4) The average multiplicity was 1.7 ± 0.1 (P < 0.001, n = 8, one-tailed one-sample t-test with test value = 1). (B1) A typical recording at 0 mV from a pyramidal cell, upper trace shows GABA sIPSCs under control conditions and lower trace shows mIPSCs after wash-in of TTX. (B2) TTX reduces the GABA IPSC amplitude by 8.4 ± 2.7 pA (P = 0.03, n = 6, two-tailed paired t-test). (B3) TTX reduces GABA IPSC frequency by 3.2 ± 0.8 Hz (P = 0.005, n = 6, one-tailed paired t-test). (B4) The average multiplicity was 2
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab120054 has been referenced in 211 publications.
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